Dexamethasone Acetate is a glucocorticoid with anti-inflammatory properties. One possible mode of action of the anti-inflammatory properties has been documented by Dexamethasone Acetate inhibitiing upregulation of ICAM-1 (intercellular adhesion molecule-1) in cultured human mast cells. The compound also displays anti mitotic activity against chemically transformed mouse fibroblasts by halting mitosis from entering the S-phase. Dexamethasone Acetate has also been determined to markedly decrease the number of activated macrophages. In addition, Dexamethasone Acetate has been observed to significantly decrease mRNA levels of TPH2 (tryptophan hydroxylase-2) in the raphe nuclei of C57/Bl6 mice. References: 1. Fagot, D., et al. 1991. Endocrinology. 129: 1033-1041. PMID: 1906802 2. Roberts, C.P., et al. 1996. Am. J. Obstet. Gynecol. 175: 248-257. PMID: 8765239 3. Inamura, H., et al. 2001. Allergy. 56: 672-678. PMID: 11421927 4. Clark, J.A., et al. 2008. Mol. Psychiatry. 13: 498-506. PMID: 17622221 5. Wang, M.T., et al. 2010. Int J. Nanomedicine. 5: 487-497. PMID: 20957171 CAS No.1177-87-3 Chemical Name:Dexamethasone-17-acetate SynonymsDEXAMETHASONE ACETATE;DEXAMETHASON ACETATE;DEXAMETHASONE 21-ACETATE;9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate;Dectan;Panasone;Dectancyl;NSC 39471;Decadronal;Decadron-la CBNumber:CB9703269 Molecular Formula:C24H31FO6 Molecular Weight:434.5 MDL Number:MFCD00027407 MOL File:1177-87-3.mol
